The use of the diet drug with an allergy or some kind of hypersensitivity to any of the components of the African Mango, caused mild side effects and drowsiness also including adverse effects like headaches, dry mouth, GL complaints, sleep disturbance and flu-like symptoms.  One report detected fungi and afla toxins in bush mango seeds sold in eastern Nigeria which are also unacceptable for human consumption.

People suggested that there is no such magic pill that does everything for a person and that Exercise, eating sensibly are always supposed to be the key factors in improving the health and diet all over. Only limited information being available on the drug interactions, theoretically the drug may enhance the side effects of medication of diabetes and cholesterol. Additive side effects may also seen in patients being treated for obesity. Because African Mango, delays the stomach emptying, the patients getting prescribed medications should use the diet drug with caution. The information regarding the take of the drug and of the safety during pregnancy and lactation is lacking. Extra does of the medicine have also reportedly caused diarrhea and stomach flu. The long term effects of this drug are not yet known since it very new to the market.

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